Acetonitrile (ACN)
CH₃CN · CAS 75-05-8
Premium acetonitrile across nine grades. Exceptionally low UV absorbance at 200–254 nm, minimal water content, and near-zero residue make it the definitive HPLC and LC-MS/MS mobile phase for pharmaceutical QC, bioanalytical, environmental, and food safety applications.
Molecular Weight
41.05 g/mol
Boiling Point
81.6 °C
Density
0.786 g/mL
Molecular Formula
Available Grades
Analytical Specification
Analytical Specification Table
All values represent maximum allowable limits unless noted ≥. A lot-specific Certificate of Analysis (CoA) with ICP-MS, LPC, and GC data is issued for every shipment. Full data packages available on request.
| Parameter | Test Method | Unit | HPLC-G | HPLC | AR |
|---|---|---|---|---|---|
| Assay (GC) | GC-FID | % | — | ≥99.9 | ≥99.5 |
| Water Content (KF) | Karl Fischer | ppm | ≤30 | ≤50 | ≤500 |
| UV Absorbance 190 nm | UV-Vis | AU | ≤1.00 | ≤1.00 | — |
| UV Absorbance 200 nm | UV-Vis | AU | ≤0.50 | ≤0.50 | — |
| UV Absorbance 210 nm | UV-Vis | AU | ≤0.10 | ≤0.20 | — |
| UV Absorbance 230 nm | UV-Vis | AU | ≤0.03 | ≤0.05 | — |
| UV Absorbance 254 nm | UV-Vis | AU | ≤0.005 | ≤0.01 | — |
| Acidity (as HAc) | Titration | ppm | — | ≤2 | ≤5 |
| Acrylonitrile | GC-MS | ppm | — | ≤1 | ≤5 |
| Residue on Evaporation | Gravimetric | ppm | — | ≤1 | ≤5 |
★ G5 = SEMI C1 Tier D (6N grade). All metal values by ICP-MS. Particle counts by in-line LPC during ISO Class 3 fill. CoA available on request.
Grade Comparison
G1 → G5 Purity Scale
Select the grade that matches your process node and contamination budget. Every grade is available from PureTech with full lot CoA and ICP-MS data.
All grades tested by ICP-MS (28 elements), in-line LPC (ISO Class 3 fill), and Karl Fischer titration. G5 = SEMI C1 Tier D. Full CoA per lot. Request CoA template →
Application Areas
Where Acetonitrile Is Used
Semiconductor Process
- Photoresist developer co-solvent research
- organic thin-film characterization
Laboratory & Analytical
- HPLC reverse-phase mobile phase (RP-HPLC)
- UHPLC sub-2-μm particle column applications
- LC-MS/MS pharmaceutical API and metabolite analysis
- Proteomics & peptide LC-MS
- DNA & oligonucleotide RP-IP-HPLC
- Environmental contaminant screening (EPA methods)
- Food safety pesticide/mycotoxin residue testing
- Clinical bioanalytical assays (plasma protein precipitation)
- Chiral HPLC with polysaccharide columns
Industrial & Other
- Pharmaceutical API release testing
- CRO bioanalytical services
- agrochemical residue analysis
Battery & Energy Storage
Packaging & Supply
Available Container Formats
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Our application engineers respond with full CoA data, ICP-MS reports, and supply chain details within one business day.