Pharmaceutical & HPLC Laboratory
Analytical Grade Solvents for Pharma QC
Pharmaceutical analytical laboratories require the highest quality HPLC and LC-MS grade solvents for API characterization, impurity profiling, dissolution testing, and bioanalytical assays.
Key Challenges
What Makes Pharmaceutical & HPLC Laboratory Chemistry Demanding
UV Baseline Stability
Gradient HPLC methods are sensitive to UV-absorbing impurities. HPLC-G grade acetonitrile (UV 254nm ≤0.005 AU) prevents baseline drift.
LC-MS Background
LC-MS/MS quantitation at pg/mL concentrations requires mobile phase with zero chemical background. LC-MS grade ACN (acrylonitrile ≤1 ppm) minimizes noise.
Product Portfolio
Chemicals for Pharmaceutical & HPLC Laboratory
Process Mapping
Step-by-Step Chemical Guide
RP-HPLC Mobile Phase
Acetonitrile HPLC-GUV detection at 210–280nm. HPLC-G provides UV 210nm ≤0.10 AU for flat gradient baseline.
LC-MS/MS Bioanalysis
Acetonitrile LC-MSPlasma protein precipitation and LC-MS/MS mobile phase. Acrylonitrile ≤1 ppm minimizes background.
Peptide Synthesis
DCM PharmaFmoc/Boc solid-phase peptide synthesis. UV 254nm ≤0.01 AU.
FAQ
Frequently Asked Questions
What is the difference between HPLC grade and LC-MS grade acetonitrile?
HPLC grade: UV 210nm ≤0.20 AU, water ≤50 ppm, acrylonitrile ≤5 ppm. Suitable for UV-based HPLC. LC-MS grade: UV 210nm ≤0.10 AU, water ≤30 ppm, acrylonitrile ≤1 ppm. Essential for mass spectrometry — lower impurity profile reduces chemical background noise in MRM channels.
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